intranasal systemic pathway, or intranasal brain pathway. med.

[dao2812]

Without wishing to be bound by theory, the inventors hypothesize that the synergistic results achieved by the disclosed methods and compositions involve increased First Pass Metabolism (FPM) of alcohol and improved elimination of acetaldehyde. Moreover, because the disclosed compositions and methods are surprisingly effective at rapidly reducing BAC with test subjects reporting a highly accelerated recovery from the effects of alcohol consumption, the inventors hypothesize that an additional pathway may be involved that eliminates alcohol vapors and/or prevents "alcohol vapor absorption in the aerodigestive tract, intranasal systemic pathway, or intranasal brain pathway".

Without wishing to be bound by theory, the inventors hypothesize that the synergistic results achieved by the disclosed methods and compositions result from an increase in First Pass Metabolism (FPM) of alcohol; elimination of alcohol vapors in the aerodigestive tract, intranasal systemic pathway, or intranasal brain pathway; and/or improved elimination of acetaldehyde. It is believed that the mechanism of action involves the activity of alcohol dehydrogenase enzymes (e.g., one or more of ADH1-7).

Thus, probiotics that can survive and function in the human digestive tract (e.g., anaeorobic probiotics); function in FPM; "function in the aerodigestive tract, intranasal systemic pathway, or intranasal brain pathway"; and/or provide significant alcohol dehydrogenase activity (such as provided by one or more of ADH1-7) are expected to be useful in the disclosed methods and compositions.

Particular ADH enzymes that may be useful include enzymes that function in FPM or function in the aerodigestive enzymes that function in intranasal systemic pathway, or intranasal brain pathway.

ADH - алкогольдегидрогеназа
BAC - blood alcohol content

Как перевести "enzymes that function in intranasal systemic pathway, or intranasal brain pathway"?

alcohol vapor absorption in the aerodigestive tract, intranasal systemic pathway, or intranasal brain pathway?
Ответ, полученный на kudoz не подходит.

Спасибо!

[leka11]

aerodigestive tract - аэродигестивный тракт (The mixed airway/gastrointestinal tract..... )
http://medical-dictionary.thefreedictionary.com/Aerodigestive+Tract

[dao2812]

Меня интересует intranasal systemic pathway, or intranasal brain pathway

[leka11]

в принципе на кудозе Вам ответили правильно, просто надо подумать и немного адаптировать к вашему случаю

"Интраназальный способ доставки ..... часть препарата поступает напрямую в головной мозг по интранейрональному пути – за счёт активного поглощения обонятельным ....нервом "

[Shokolapka]

intranasal systemic pathway - всасывание в системный кровоток через сосуды слизистой оболочки носовой полости. Т.е. применяется местно, но действует на весь организм (если речь о лекарствах). Возможно, можно дословно перевести как интразальный системный путь действия
intranasal brain pathway - прямое поступление вещества в мозг, минуя ГЭБ (периневральный транспорт по чувствительным нервам - вещество попадает непосредственно в мозг через нейроны обонятельного тракта и далее распространяется по структурам головного мозга при помощи механизмов, не связанных с кровотоком)